Pathogenesis of Primary (Idiopathic) PAP
This is a list of articles published in the scientific and medical literature. Please note the following: (1) articles are arranged in reverse chronological order; (2) the list is by no means exhaustive but represents key articles; (3) references are provided for educational purposes only and are not intended to replace medical advice regarding diagnosis or treatment of PAP.
Most articles can be viewed directly by clicking on the underlined URL hyperlink (blue underlined text) below each citation. In most cases, you will be directed to a web page containing the abstract of the report. Some articles will then have another link termed ‘Full Text’ which will open a web-site containing the full length article. Those without a ‘Full Text’ link will provide the article’s standard citation allowing it to be accessed by other means.
High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis
Uchida K, Nakata K, Trapnell BC, Terakawa T, Hamano E, Mikami A, Matsushita I, Seymour JF, Oh-Eda M, Ishige I, Eishi Y, Kitamura T, Yamada Y, Hanaoka K and Keicho N
Blood 2004;103:1089-98
Autoantibodies against granulocyte macrophage colony-stimulating factor are diagnostic for pulmonary alveolar proteinosis
Bonfield TL, Russell D, Burgess S, Malur A, Kavuru MS and Thomassen MJ
Am J Respir Cell Mol Biol 2002;27:481-6
GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
Shibata Y, Berclaz PY, Chroneos ZC, Yoshida M, Whitsett JA and Trapnell BC
Immunity 2001;15:557-67
Therapeutic efficacy of granulocyte-macrophage colony-stimulating factor in patients with idiopathic acquired alveolar proteinosis
Seymour JF, Presneill JJ, Schoch OD, Downie GH, Moore PE, Doyle IR, Vincent JM, Nakata K, Kitamura T, Langton D, Pain MC and Dunn AR
Am J Respir Crit Care Med 2001;163:524-31
Impaired functional activity of alveolar macrophages from GM-CSF-deficient mice
Paine R, 3rd, Morris SB, Jin H, Wilcoxen SE, Phare SM, Moore BB, Coffey MJ and Toews GB
Am J Physiol Lung Cell Mol Physiol 2001;281:L1210-8
Serological diagnosis of idiopathic pulmonary alveolar proteinosis
Kitamura T, Uchida K, Tanaka N, Tsuchiya T, Watanabe J, Yamada Y, Hanaoka K, Seymour JF, Schoch OD, Doyle I, Inoue Y, Sakatani M, Kudoh S, Azuma A, Nukiwa T, Tomita T, Katagiri M, Fujita A, Kurashima A, Kanegasaki S and Nakata K
Am J Respir Crit Care Med 2000;162:658-62
Exogenous granulocyte-macrophage colony-stimulating factor administration for pulmonary alveolar proteinosis
Kavuru MS, Sullivan EJ, Piccin R, Thomassen MJ and Stoller JK
Am J Respir Crit Care Med 2000;161:1143-8
Detection of granulocyte-macrophage colony-stimulating factor in patients with pulmonary alveolar proteinosis
Carraway MS, Ghio AJ, Carter JD and Piantadosi CA
Am J Respir Crit Care Med 2000;161:1294-9
GM-CSF and GM-CSF beta c receptor in adult patients with pulmonary alveolar proteinosis
Bewig B, Wang XD, Kirsten D, Dalhoff K and Schafer H
Eur Respir J 2000;15:350-7
Lungs of patients with idiopathic pulmonary alveolar proteinosis express a factor which neutralizes granulocyte-macrophage colony stimulating factor
Tanaka N, Watanabe J, Kitamura T, Yamada Y, Kanegasaki S and Nakata K
FEBS Lett 1999;442:246-50
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9929010
Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor
Kitamura T, Tanaka N, Watanabe J, Uchida, Kanegasaki S, Yamada Y and Nakata K
J Exp Med 1999;190:875-80
Elevated bronchoalveolar concentrations of MCP-1 in patients with pulmonary alveolar proteinosis
Iyonaga K, Suga M, Yamamoto T, Ichiyasu H, Miyakawa H and Ando M
Eur Respir J 1999;14:383-9
Defective expression of granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 receptor common beta chain in children with acute myeloid leukemia associated with respiratory failure
Dirksen U, Hattenhorst U, Schneider P, Schroten H, Gobel U, Bocking A, Muller KM, Murray R and Burdach S
Blood 1998;92:1097-103
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9694696
Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression
Dirksen U, Nishinakamura R, Groneck P, Hattenhorst U, Nogee L, Murray R and Burdach S
J Clin Invest 1997;100:2211-7
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9410898
Efficacy of granulocyte-macrophage colony-stimulating factor in acquired alveolar proteinosis
Seymour JF, Dunn AR, Vincent JM, Presneill JJ and Pain MC
N Engl J Med 1996;335:1924-5
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8965913
Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis
Dranoff G, Crawford AD, Sadelain M, Ream B, Rashid A, Bronson RT, Dickersin GR, Bachurski CJ, Mark EL, Whitsett JA and et al.
Science 1994;264:713-6
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8171324
A macrophage-suppressing 40-kD protein in a case of pulmonary alveolar proteinosis
Muller-Quernheim J, Schopf RE, Benes P, Schulz V and Ferlinz R
Klin Wochenschr 1987;65:893-7
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3323640
Pulmonary alveolar proteinosis. Further evaluation of abnormal alveolar macrophages
Gonzalez-Rothi RJ and Harris JO
Chest 1986;90:656-61
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3769565
Macrophage function in pulmonary alveolar proteinosis
Nugent KM and Pesanti EL
Am Rev Respir Dis 1983;127:780-1
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6859660
The immunoinhibitory activities of the lung lavage materials and sera from patients with pulmonary alveolar proteinosis (PAP)
Stratton JA, Sieger L and Wasserman K
J Clin Lab Immunol 1981;5:81-6
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6894313
Pulmonary alveolar proteinosis: abnormal in vitro function of alveolar macrophages
Harris JO
Chest 1979;76:156-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=456053
Alveolar proteinosis and the overfed macrophage
Golde DW
Chest 1979;76:119-20
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=456046
Defective lung macrophages in pulmonary alveolar proteinosis
Golde DW, Territo M, Finley TN and Cline MJ
Ann Intern Med 1976;85:304-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=183578
Pulmonary Alveolar Proteinosis. Report of Six Cases, Review of the Literature, and Formulation of a New Theory
Larson RK and Gordinier R
Ann Intern Med 1965;62:292-312
Pulmonary alveolar proteinosis. A review of the findings and theories to date, with a digression on Pneumocystis carinii pneumonia
De Sanctis PN
Bmq 1962;13:19-35