Mouse Models of PAP
This is a list of articles published in the scientific and medical literature. Please note the following: (1) articles are arranged in reverse chronological order; (2) the list is by no means exhaustive but represents key articles; (3) references are provided for educational purposes only and are not intended to replace medical advice regarding diagnosis or treatment of PAP.
Most articles can be viewed directly by clicking on the underlined URL hyperlink (blue underlined text) below each citation. In most cases, you will be directed to a web page containing the abstract of the report. Some articles will then have another link termed ‘Full Text’ which will open a web-site containing the full length article. Those without a ‘Full Text’ link will provide the article’s standard citation allowing it to be accessed by other means.
GM-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense
Trapnell BC and Whitsett JA
Annu Rev Physiol 2002;64:775-802
GM-CSF, via PU.1, regulates alveolar macrophage Fcgamma R-mediated phagocytosis and the IL-18/IFN-gamma -mediated molecular connection between innate and adaptive immunity in the lung
Berclaz PY, Shibata Y, Whitsett JA and Trapnell BC
Blood 2002;100:4193-200
Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by
GM-CSF and PU.1Berclaz PY, Zsengeller Z, Shibata Y, Otake K, Strasbaugh S, Whitsett JA and Trapnell BC
J Immunol 2002;169:6332-42
GM-CSF regulates protein and lipid catabolism by alveolar macrophages
Yoshida M, Ikegami M, Reed JA, Chroneos ZC and Whitsett JA
Am J Physiol Lung Cell Mol Physiol 2001;280:L379-86
GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
Shibata Y, Berclaz PY, Chroneos ZC, Yoshida M, Whitsett JA and Trapnell BC
Immunity 2001;15:557-67
Impaired functional activity of alveolar macrophages from GM-CSF-deficient mice
Paine R, 3rd, Morris SB, Jin H, Wilcoxen SE, Phare SM, Moore BB, Coffey MJ and Toews GB
Am J Physiol Lung Cell Mol Physiol 2001;281:L1210-8
Granulocyte-macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice
Paine R, 3rd, Preston AM, Wilcoxen S, Jin H, Siu BB, Morris SB, Reed JA, Ross G, Whitsett JA and Beck JM
J Immunol 2000;164:2602-9
Regulation of B lymphocyte and macrophage development by graded expression of PU.1
DeKoter RP and Singh H
Science 2000;288:1439-41
Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice
Reed JA, Ikegami M, Cianciolo ER, Lu W, Cho PS, Hull W, Jobe AH and Whitsett JA
Am J Physiol 1999;276:L556-63
The key role of PU.1/SPI-1 in B cells, myeloid cells and macrophages
Lloberas J, Soler C and Celada A
Immunol Today 1999;20:184-9
GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection
LeVine AM, Reed JA, Kurak KE, Cianciolo E and Whitsett JA
J Clin Invest 1999;103:563-9
Adenovirus-mediated granulocyte-macrophage colony-stimulating factor improves lung pathology of pulmonary alveolar proteinosis in granulocyte-macrophage colony-stimulating factor-deficient mice
Zsengeller ZK, Reed JA, Bachurski CJ, LeVine AM, Forry-Schaudies S, Hirsch R and Whitsett JA
Hum Gene Ther 1998;9:2101-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9759936
Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor
Armitage JO
Blood 1998;92:4491-508
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9845514
Myeloid development is selectively disrupted in PU.1 null mice
Anderson KL, Smith KA, Conners K, McKercher SR, Maki RA and Torbett BE
Blood 1998;91:3702-10
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9573007
GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice
Huffman Reed JA, Rice WR, Zsengeller ZK, Wert SE, Dranoff G and Whitsett JA
Am J Physiol 1997;273:L715-25
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9357845
Granulocyte-macrophage colony-stimulating factor and the immune system
Tarr PE
Med Oncol 1996;13:133-40
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9106171
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
McKercher SR, Torbett BE, Anderson KL, Henkel GW, Vestal DJ, Baribault H, Klemsz M, Feeney AJ, Wu GE, Paige CJ and Maki RA
Embo J 1996;15:5647-58
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8896458
Surfactant metabolism in transgenic mice after granulocyte macrophage-colony stimulating factor ablation
Ikegami M, Ueda T, Hull W, Whitsett JA, Mulligan RC, Dranoff G and Jobe AH
Am J Physiol 1996;270:L650-8
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8928826
Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice
Huffman JA, Hull WM, Dranoff G, Mulligan RC and Whitsett JA
J Clin Invest 1996;97:649-55
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8609219
The transcription factor PU.1 is involved in macrophage proliferation
Celada A, Borras FE, Soler C, Lloberas J, Klemsz M, van Beveren C, McKercher S and Maki RA
J Exp Med 1996;184:61-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8691150
Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5
Robb L, Drinkwater CC, Metcalf D, Li R, Kontgen F, Nicola NA and Begley CG
Proc Natl Acad Sci U S A 1995;92:9565-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7568173
Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal
Nishinakamura R, Nakayama N, Hirabayashi Y, Inoue T, Aud D, McNeil T, Azuma S, Yoshida S, Toyoda Y, Arai K and et al.
Immunity 1995;2:211-22
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7697542
Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology
Stanley E, Lieschke GJ, Grail D, Metcalf D, Hodgson G, Gall JA, Maher DW, Cebon J, Sinickas V and Dunn AR
Proc Natl Acad Sci U S A 1994;91:5592-6
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8202532
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott EW, Simon MC, Anastasi J and Singh H
Science 1994;265:1573-7
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8079170
Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis
Dranoff G, Crawford AD, Sadelain M, Ream B, Rashid A, Bronson RT, Dickersin GR, Bachurski CJ, Mark EL, Whitsett JA and et al.
Science 1994;264:713-6
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8171324
Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1
Hromas R, Orazi A, Neiman RS, Maki R, Van Beveran C, Moore J and Klemsz M
Blood 1993;82:2998-3004
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8219191
A model for the interaction of the GM-CSF, IL-3 and IL-5 receptors with their ligands
Goodall GJ, Bagley CJ, Vadas MA and Lopez AF
Growth Factors 1993;8:87-97
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8466757
Granulocyte-macrophage colony-stimulating factor: pleiotropic cytokine with potential clinical usefulness
Ruef C and Coleman DL
Rev Infect Dis 1990;12:41-62
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2405468
The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
Klemsz MJ, McKercher SR, Celada A, Van Beveren C and Maki RA
Cell 1990;61:113-24
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2180582
Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor
Hayashida K, Kitamura T, Gorman DM, Arai K, Yokota T and Miyajima A
Proc Natl Acad Sci U S A 1990;87:9655-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1702217
Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor
Gearing DP, King JA, Gough NM and Nicola NA
Embo J 1989;8:3667-76
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2555171
Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes
Miyatake S, Otsuka T, Yokota T, Lee F and Arai K
Embo J 1985;4:2561-8
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3876930
Purification and properties of colony-stimulating factor from mouse lung-conditioned medium
Burgess AW, Camakaris J and Metcalf D
J Biol Chem 1977;252:1998-2003
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=300377
Pathogenesis of Primary (Idiopathic) PAP
High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis
Uchida K, Nakata K, Trapnell BC, Terakawa T, Hamano E, Mikami A, Matsushita I, Seymour JF, Oh-Eda M, Ishige I, Eishi Y, Kitamura T, Yamada Y, Hanaoka K and Keicho N
Blood 2004;103:1089-98
Autoantibodies against granulocyte macrophage colony-stimulating factor are diagnostic for pulmonary alveolar proteinosis
Bonfield TL, Russell D, Burgess S, Malur A, Kavuru MS and Thomassen MJ
Am J Respir Cell Mol Biol 2002;27:481-6
GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
Shibata Y, Berclaz PY, Chroneos ZC, Yoshida M, Whitsett JA and Trapnell BC
Immunity 2001;15:557-67
Therapeutic efficacy of granulocyte-macrophage colony-stimulating factor in patients with idiopathic acquired alveolar proteinosis
Seymour JF, Presneill JJ, Schoch OD, Downie GH, Moore PE, Doyle IR, Vincent JM, Nakata K, Kitamura T, Langton D, Pain MC and Dunn AR
Am J Respir Crit Care Med 2001;163:524-31
Impaired functional activity of alveolar macrophages from GM-CSF-deficient mice
Paine R, 3rd, Morris SB, Jin H, Wilcoxen SE, Phare SM, Moore BB, Coffey MJ and Toews GB
Am J Physiol Lung Cell Mol Physiol 2001;281:L1210-8
Serological diagnosis of idiopathic pulmonary alveolar proteinosis
Kitamura T, Uchida K, Tanaka N, Tsuchiya T, Watanabe J, Yamada Y, Hanaoka K, Seymour JF, Schoch OD, Doyle I, Inoue Y, Sakatani M, Kudoh S, Azuma A, Nukiwa T, Tomita T, Katagiri M, Fujita A, Kurashima A, Kanegasaki S and Nakata K
Am J Respir Crit Care Med 2000;162:658-62
Exogenous granulocyte-macrophage colony-stimulating factor administration for pulmonary alveolar proteinosis
Kavuru MS, Sullivan EJ, Piccin R, Thomassen MJ and Stoller JK
Am J Respir Crit Care Med 2000;161:1143-8
Detection of granulocyte-macrophage colony-stimulating factor in patients with pulmonary alveolar proteinosis
Carraway MS, Ghio AJ, Carter JD and Piantadosi CA
Am J Respir Crit Care Med 2000;161:1294-9
GM-CSF and GM-CSF beta c receptor in adult patients with pulmonary alveolar proteinosis
Bewig B, Wang XD, Kirsten D, Dalhoff K and Schafer H
Eur Respir J 2000;15:350-7
Lungs of patients with idiopathic pulmonary alveolar proteinosis express a factor which neutralizes granulocyte-macrophage colony stimulating factor
Tanaka N, Watanabe J, Kitamura T, Yamada Y, Kanegasaki S and Nakata K
FEBS Lett 1999;442:246-50
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9929010
Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor
Kitamura T, Tanaka N, Watanabe J, Uchida, Kanegasaki S, Yamada Y and Nakata K
J Exp Med 1999;190:875-80
Elevated bronchoalveolar concentrations of MCP-1 in patients with pulmonary alveolar proteinosis
Iyonaga K, Suga M, Yamamoto T, Ichiyasu H, Miyakawa H and Ando M
Eur Respir J 1999;14:383-9
Defective expression of granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 receptor common beta chain in children with acute myeloid leukemia associated with respiratory failure
Dirksen U, Hattenhorst U, Schneider P, Schroten H, Gobel U, Bocking A, Muller KM, Murray R and Burdach S
Blood 1998;92:1097-103
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9694696
Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression
Dirksen U, Nishinakamura R, Groneck P, Hattenhorst U, Nogee L, Murray R and Burdach S
J Clin Invest 1997;100:2211-7
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9410898
Efficacy of granulocyte-macrophage colony-stimulating factor in acquired alveolar proteinosis
Seymour JF, Dunn AR, Vincent JM, Presneill JJ and Pain MC
N Engl J Med 1996;335:1924-5
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8965913
Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis
Dranoff G, Crawford AD, Sadelain M, Ream B, Rashid A, Bronson RT, Dickersin GR, Bachurski CJ, Mark EL, Whitsett JA and et al.
Science 1994;264:713-6
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8171324
A macrophage-suppressing 40-kD protein in a case of pulmonary alveolar proteinosis
Muller-Quernheim J, Schopf RE, Benes P, Schulz V and Ferlinz R
Klin Wochenschr 1987;65:893-7
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3323640
Pulmonary alveolar proteinosis. Further evaluation of abnormal alveolar macrophages
Gonzalez-Rothi RJ and Harris JO
Chest 1986;90:656-61
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3769565
Macrophage function in pulmonary alveolar proteinosis
Nugent KM and Pesanti EL
Am Rev Respir Dis 1983;127:780-1
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6859660
The immunoinhibitory activities of the lung lavage materials and sera from patients with pulmonary alveolar proteinosis (PAP)
Stratton JA, Sieger L and Wasserman K
J Clin Lab Immunol 1981;5:81-6
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6894313
Pulmonary alveolar proteinosis: abnormal in vitro function of alveolar macrophages
Harris JO
Chest 1979;76:156-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=456053
Alveolar proteinosis and the overfed macrophage
Golde DW
Chest 1979;76:119-20
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=456046
Defective lung macrophages in pulmonary alveolar proteinosis
Golde DW, Territo M, Finley TN and Cline MJ
Ann Intern Med 1976;85:304-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=183578
Pulmonary Alveolar Proteinosis. Report of Six Cases, Review of the Literature, and Formulation of a New Theory
Larson RK and Gordinier R
Ann Intern Med 1965;62:292-312
Pulmonary alveolar proteinosis. A review of the findings and theories to date, with a digression on Pneumocystis carinii pneumonia
De Sanctis PN
Bmq 1962;13:19-35